Our information may differ from that provided by the manufacturers, because their information usually relates to adults. If you have been prescribed a modified-release form of ibuprofen (Brufen Retard® brand), swallow the tablet or capsule whole with a glass of water.

There is evidence of an increased risk of haemarthroses and haematoma in HIV (+) haemophiliacs receiving concurrent treatment with zidovudine and ibuprofen.

Pharmacotherapeutic classification: Anti-inflammatory and antirheumatic products, nonsteroidal; propionic acid derivatives. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. Undesirable effects may be minimised by using the minimum effective dose for the shortest possible duration necessary to control symptoms (see section 4. Some studies have shown that ibuprofen may increase the risk of developing serious skin infections when used in children with chickenpox. Some pharmacodynamic studies show that when single doses of ibuprofen 400mg were taken within 8 hours before or within 30 minutes after immediate release aspirin dosing (81mg), a decreased effect of aspirin on the formation of thromboxane or platelet aggregation occurred.

For infants aged 3 - 5 months medical advice should be sought if symptoms worsen or not later than 24 hours if symptoms persist. The concomitant consumption of excessive alcohol with NSAIDs, including ibuprofen, may increase the risk of adverse effects on the gastrointestinal tract, such as GI haemorrhage or the central nervous system possibly due to the additive effect. Find the right form of ibuprofen for pain relief that works for you, whether tablets, capsules or gels. Anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs): Increased risk of gastrointestinal bleeding with NSAIDs (see section 4.If you have been prescribed a sachet containing ibuprofen granules (Brufen® Effervescent Granules), mix the contents of the sachet into a glass of water to make a fizzy drink.

Methotrexate : NSAIDs may inhibit the tubular secretion of methotrexate and reduce clearance of methotrexate. Reduction of the ibuprofen dose should be considered when potent CYP2C9 inhibitors are administered concomitantly, particularly when high-dose ibuprofen is administered with either voriconazole or fluconazole. Relieving other mild to moderate pain including muscular pain, pain following surgery, nerve pain (neuralgia), migraine, headache, toothache, period pain. Take ibuprofen granules by emptying the contents of the sachet into a glass full of water to make an orange flavoured fizzy drink, stir and drink straight away.

Cardiac glycosides: NSAIDs may exacerbate cardiac failure, reduce GFR and increase plasma cardiac glycoside levels. If you need to take ibuprofen for more than 6 months, your doctor may prescribe a medicine to protect your stomach from any side effects.